The list of co-variables used to calculate the propensity score was the same as in the original publication, and included age, geographic region of enrolment, height, body mass index, smoking status, atrial fibrillation/flutter, history of congestive heart failure, treated hypertension, use of lipid-lowering agents, anti-platelet agents, oral anti-coagulants, non-steroidal anti-inflammatory agents, diuretics, cardiovascular agents, peripheral arterial claudication medications, insulin, and use of other anti-diabetic agents. The gene discussed is INS; the disease is hypertensive disorder.