huAB1 also significantly reduced production of the chemokines CXCL-8, GCP-2, MIG, IP-10, CCL-2, CCL-7, and MMP-9 in RA synovial tissue (Fig. 5e), and we observed a trend towards a reduction in production of TNF, IL-1β, ENA-78 and MMP-2, although the differences were not significant (Fig. 5f). This evidence concerns the gene CCL2 and rheumatoid arthritis.