Overexpression of Prickle1 or Vangl2 significantly inhibited neuroblastoma cell growth compared to cDNA control transfected cells in SK-N-AS (Prickle1 26 % and Vangl2 44 %), SH-EP1 (Prickle1 38 % and Vangl2 60 %), SK-N-BE (2) (Prickle1 53 % and Vangl2 58 %) and SK-N-DZ (Prickle1 83 % and Vangl2 94 %) (Fig. 2b). Here, VANGL2 is linked to neuroblastoma.