TGFB1 and neoplasm: In contrast to the untreated control, naringenin and 1D11 treatments decreased the incidence of pulmonary metastasis in tumor-bearing mice on day 24 and day 34 (for 4T1/TGF-β1 tumor-bearing mice on day 24: 57 % (4/7) in control group, 14 % (1/7) in naringenin group, and 29 % (2/7) in 1D11 group; for 4T1/RFP tumor-bearing mice on day 34: 100 % (7/7) in control group, 29 % (2/7) in naringenin group, and 43 % (3/7) in 1D11 group) (Additional file 4: Table S1).