The results showed that naringenin significantly decreased TGF-β1 secretion and increased intracellular TGF-β1 concentrations in multiple human breast cancer cells, including MCF7, MDA-MB-231, MDA-MB-436, and MDA-MB-468 cells, but not in 293T and MDCK cells (Additional file 7: Figure S5). This evidence concerns the gene TGFB1 and breast carcinoma.