Secondly, in those 10 patients with MND (patients # 27–36), 1 with FTD + MND (patient #57) and 3 with FTD (patients #77–79), where both tau AND amyloid pathology was present, the pattern and distribution of tau pathology within the temporal lobe (and other regions when present) was of the type associated with Alzheimer’s disease, ie neurofibrillary tangles, neuropil threads and occasionally neuritic plaques. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.