MAPT and amyotrophic lateral sclerosis: In patients with ALS alone, an antibody directed against tau phosphorylated at Thr175 (pThr175) detected limited neuronal tau aggregates predominantly within entorhinal cortex and amygdala, whereas an antibody directed against tau phosphorylated at Thr217 (pThr217) detected astrocytic tau deposition in frontal cortex as well as in entorhinal cortex and amygdala.