Conversely, there were 3 patients with MND (patients #15–17) and 2 with FTD (patients #69 and 70) who showed amyloid plaque formation without tau pathology, 2 being at Thal phase 1 (patients #15 and 16) and 3 being at Thal phase 2 (patients #15, 69 and 70). This evidence concerns the gene MAPT and frontotemporal dementia.