MAPT and early-onset autosomal dominant Alzheimer disease: Firstly, in those 9 patients with MND (patients #18–26), 6 with MND + FTD (patients #51–56) and 6 with FTD (patients #71–76), where minimal temporal lobe tau (Braak stage 0-I/I) but no amyloid plaque pathologies were present, the tau changes might be simply considered to be ‘age-related’ and unlikely to be associated with (early stage) Alzheimer’s disease, given the lack of amyloid pathology [23].