MAPT and amyotrophic lateral sclerosis: In the ALS patients, they observed a limited number of intraneuronal tau inclusions (neurofibrillary tangles) and neuropil threads in temporal lobe structures, mostly in entorhinal cortex, and amygdala, less so in hippocampus and frontal and cingulate cortex in 1–3/5 cases, which were broadly similarly immunoreactive with all 3 antibodies.