Eleven patients (27 %) with MND (patients #18–25 and #27–29), 7 patients (44 %) with FTD + MND (patients #51–57) and 9 with FTD (39 %) showed sparse tau neuronal pathology (ie a single or a few neurofibrillary tangles and/or a few neuropil threads per section, usually only in a single brain region, and then most often in the entorhinal cortex) with any, or all, of the 3 tau antibodies employed. This evidence concerns the gene MAPT and frontotemporal dementia.