In the present study we have shown there to be ‘significant’ neuronal tau pathology in 59 % patients with MND, 44 % patients with FTD + MND and 44 % patients with FTD, whereas some degree of amyloid pathology was present in only 34 % patients with MND, 7 % patients with FTD + MND and 26 % patients with FTD. Here, MAPT is linked to mild neurocognitive disorder.