In an analysis of nearly 500 ovarian tumors and normal ovarian tissues by In situ hybridization and Immunohistochemical staining in Tissue Array format, we found that the PRSS8 gene and PRSS8 protein (prostasin) were both significantly upregulated in the majority of ovarian tumors (Fig. 1c). This evidence concerns the gene PRSS8 and ovarian neoplasm.