Although a previous study found that activation of the Hh pathway is an important determinant of FoxM1 expression in basal cell carcinoma cells [26], our study as presented here for the first time shows that Gli2 directly activates FoxM1 by binding to the Gli consensus sequence (5′-GACCACCCA-3′) in HCC cells. The gene discussed is GLI1; the disease is hepatocellular carcinoma.