GLI2 and hepatocellular carcinoma: To further determine the biological role of the Gli2-KIF20A axis in HCC growth, we established xenograft HCC tumor models by employing three stable doxycycline-inducible HCC-LM3 cell lines that express Lenti-shRNA-control, Lenti-shRNA-Gli2 and Lenti-shRNA-KIF20A (Figure 4A).