MTOR and pachyonychia congenita: Relationship between androgens and PC has established the basis for the current treatment of androgen deprivation in advanced PC [3], where several studies have shown that androgens promote PC cell growth through different mechanisms, such as induction of autophagy by androgen-mediated increases in reactive oxygen species [4] or targeting of rapamycin (mTOR) activation and post-transcriptional increases in cyclin D proteins [5].