As shown in Figure 6I and 6J, E-boxes P2, P3, P4, P6 and P7 in the Akt1 promotor region in both SiHa-Slug and C33A-Slug cells had significantly stronger trans-suppression activities than their respective control cells (Figure 6I and 6J; p < 0.05), suggesting that Slug could trans-suppress Akt1/p-Akt1 expression through the E-boxes in the Akt1 promoter region in cervical cancer cells. The gene discussed is SNAI2; the disease is cervical carcinoma.