SNAI2 and neoplasm: In conclusion, this is the first study to demonstrate that Slug may trans-suppress Akt1/p-Akt1 expression by binding to the E-boxes in the Akt1 promoter region and inhibit the proliferation and tumor formation of human cervical cancer cells by up-regulating p21/p27 and/or down-regulating the activity of the Wnt/β-catenin signaling pathway (Figure 6M).