Moreover, mRNA levels of cyclin D1 were found to be much lower in the SiHa-Slug, C33A-Slug, HeLa-shControl and CasKi-shControl cells than in the SiHa-GFP, C33A-GFP, HeLa-shSlug and CasKi-shSlug cells, respectively (Figure S1B, S1C, S1D and S1E; P < 0.05), indicating that Slug could suppress cell proliferation and tumor formation through the Akt1/p-Akt1/GSK3β/Wnt/β-catenin signaling pathway/cyclin D1 in cervical carcinoma. The gene discussed is GSK3B; the disease is cervical carcinoma.