Our recent analysis indicated that naïve CD8+ T cell is very low and terminal CD8+ T cells very high in LGL leukemia (data not shown), such cytokine alteration and T cell phenotype pattern are quite similar as that MDS does, such type of MDS patients may have a worse body's ability to fight infections and be more inclined to transform to AML. This evidence concerns the gene CD8A and acute myeloid leukemia.