TP53 and American trypanosomiasis: While in the “Consensus Knockdown Connections” gene set of DAC, numerous pathways were enriched, including “pathways in cancer”, “cell cycle”, “p53 signaling pathway”, “metabolic pathways”, “T cell receptor signaling pathway”, “epithelial cell signaling in Helicobacter pylori infection”, “neurotrophin signaling pathway”, “Chagas disease (American trypanosomiasis)”, and “osteoclast differentiation”.