Through the bioinformatic analysis, as shown in Supplementary Table S3, tumor suppressors ATRX, SLC45A2, and TNRC6B were predicted targets of miR-628-3p, and oncogenes IL1A, Smad2, Smad5, MUC17, CDC14B, and NR5A2 were targeted sequence of miR-532. The gene discussed is SMAD5; the disease is neoplasm.