Fasudil, which has potent vasodilatory effects and is approved in Japan for the treatment of subarachnoid hemorrhage, and the experimentally used ROCK inhibitor Y-27632 block the cytoskeletal remodeling and fibronectin deposition upon TGFβ-treatment though only in the micromolar range due to their higher IC50 values for ROCK inhibition (Figure 3, Figure 7). This evidence concerns the gene TGFB1 and subarachnoid hemorrhage.