In conclusion, TPA-induced migration of MCF-7 breast cancer cells is associated with the up-regulation of fascin-1 gene transcription, which is mediated through the activation of the PKCδ/STAT3α, PKCδ/GSK3β/β-catenin, and Wnt-1/β-catenin signaling pathways. The gene discussed is GSK3B; the disease is breast carcinoma.