This could be supported by the fact that the cytomegalovirus (CMV) enhancer/promoter for transgenic hPRDX4 cDNA is stimulated by enhanced ROS and inflammation during the progression of NAFLD in this dietary model, via cross-talk with other promoters for many transcription factor binding sites, such as the two activator protein 1 (AP1), four NFκB and five cAMP response element binding protein (CREB) binding sites, as described previously [5,6,27]. Here, CREB1 is linked to metabolic dysfunction-associated steatotic liver disease.