Based on our current data in this MCD+HF diet-induced NAFLD mouse model, we could provide the first evidence that the small intestine and liver are spared to some degree by the antioxidant properties of PRDX4, and overexpression of PRDX4 beneficially affects intestinal function in the reduction of the severity of NAFLD. Here, PRDX4 is linked to hydrops fetalis.