Furthermore, since the ApoB and MTP activity in the ER are also known to play a crucial role in the efficient assembly and secretion of lipoproteins into chylomicrons [13,33], the present data could be in line with the beneficial effects of intestinal function in the Tg mice during the development of the MCD+HF diet-induced NAFLD model. The gene discussed is APOB; the disease is metabolic dysfunction-associated steatotic liver disease.