We have recently established human PRDX4 (hPRDX4) transgenic (Tg) mice on a C57BL/6 background [5,6,25,26] and investigated the diverse protective roles of PRDX4 against a nongenetic mouse model of NASH and insulin resistance by feeding the mice a high-fructose diet after injecting a relatively low dose of streptozotocin [6]. Here, PRDX4 is linked to metabolic dysfunction-associated steatohepatitis.