Furthermore, with regard to LXR-α, which was predominantly expressed in tissues involved in lipid metabolism, such as the liver and small intestine [35,37], the present data are in agreement with the previously reported findings; activation of LXR-α plays a central role in hepatic lipogenesis, causing hepatic steatosis and the development of intrahepatic inflammation [38]. Here, NR1H3 is linked to Hepatic steatosis.