Although IFN-γ is considered to be unable to distinguish active TB from LTBI, our present study found that IL-1RA, IL-2, IL-5, MCP-1 and IL-10—in addition to IFN-γ—are good candidates; especially when analyzed in combination, they increase the diagnostic potential of QFT for discriminating active TB from LTBI. Here, IL2 is linked to tuberculosis.