According to our findings, the NOTCH1 SMs in patients were not only associated with higher risks of cancer recurrence and lower survival in 5-year (Fig. 3) and 10-year (Fig. S5) Kaplan Meier survival estimates but also had a significant predictive power in multivariate Cox regression for both cancer recurrence and death after controlling for patient- and hospital-confounders (Table 2). This evidence concerns the gene NOTCH1 and cancer.