NOTCH1 and head and neck squamous cell carcinoma: Additionally, SNP rs139994842 showed a moderate correlation coefficient with these 5 NOTCH1 SMs (D’ = 1; r = 0.63; P = 0.0004) as well as significantly associated with increased risk of HNSCC (OR = 3.46; 95% CI, 1.11–10.84) (Table 3).