Here, we demonstrate that CADM1 inhibits SqCC progression via a mechanism involving HER2 and ITGα6β4-mediated STAT3 inhibition (Fig. 7).Our results indicate that the extracellular domain of CADM1 is responsible for suppressing tumour progression, consistent with previous studies of human colorectal cancer cells14, 15. Here, STAT3 is linked to neoplasm.