A couple of them have shown that GM-CSF/IL-4-induced BMDC from B6.Sle1.Sle2.Sle3 lupus-prone mice, compared to BMDC from B6 mice, promoted better B cells proliferation and IgM/IgG production in in vitro coculture system upon anti-CD40 ligation [81, 82]. The gene discussed is CD40LG; the disease is systemic lupus erythematosus.