However, both the anti-RAGE antibody and 4-PBA downregulated the expression of GRP-78 and CHOP, suggesting that efficient suppression resulted from either blocking the CML-RAGE pathway or inhibiting ERS (Figures 5(a), 5(b), and 5(c)). The gene discussed is HSPA5; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.