LDLR and chronic myelogenous leukemia, BCR-ABL1 positive: When we used 4-PBA to inhibit ERS, we found that 4-PBA downregulated the CML-induced upregulation of SREBP-2, nSREBP-2 HMG-CoAR, and LDLr in HK-2 cells, suggesting that inhibiting ERS reduces the abnormal cellular cholesterol uptake and synthesis associated with CML.