Next, we examined the effects of CML on the expression levels of SREBP-2, HMG-CoAR, LDLr, LXR, and ABCA1, and we also used an anti-RAGE antibody to block the CML-RAGE pathway to determine the effects of CML on cellular cholesterol uptake, synthesis, and efflux. Here, LDLR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.