As shown in Table 1, CH and CKD rats had significantly increased this ratio (Nx5/6: 0.52 ± 0.03 versus Sham: 0.32 ± 0.04; CH + IC: 0.58 ± 0.13, CH: 0.58 ± 0.11 versus Citrate: 0.34 ± 0.05). The gene discussed is C4B; the disease is chronic kidney disease.