APP and early-onset autosomal dominant Alzheimer disease: WAVE1 acts downstream of Nerve Growth Factor and of the RAC1 GTPase to regulate actin filament reorganization and axonal filopodia formation via its interaction with the Arp2/3 complex [99] and controls dendritic spine morphology and neural activity-induced mitochondrial distribution in dendritic spines [100, 101]. WAVE1 transcription is negatively regulated by the amyloid precursor protein intracellular domain, and WAVE1 protein depletion dramatically reduces amyloid beta levels and restores memory deficits in a mouse model of Alzheimer's disease [102].