For future research it would therefore be interesting to study the effect of the Fortasyn diet in older (24 months of age) apoE4 mice, in apoE4 mice with induced apoE4 comorbidities like hypertension, stroke, or in apoE4 mice on high-fat diet or in female apoE4 mice, resembling more closely the human susceptibility to AD. The gene discussed is APOE; the disease is hypertensive disorder.