For example, in vitro experiments indicate that the effects of stress/GC are mediated by glycogen synthase kinase 3 (GSK3) and cyclin-dependent kinase 5 (CDK5), both of which have well-established roles in Tau hyperphosphorylation and the subsequent disruption of microtubules, features seen in the AD brain [82]. This evidence concerns the gene CDK5 and Alzheimer disease.