It has been documented that Aβ42 oligomers induce dendritic spine loss and microtubule-associated protein tau hyperphosphorylation by the calcium/calmodulin-dependent protein kinase kinase 2, adenosine monophosphate-activated protein kinase (CAMKK2-AMPK) signaling cascade, which is tightly associated with synaptic plasticity alteration in AD progression [87, 88]. This evidence concerns the gene CAMKK2 and Alzheimer disease.