In RCC cell culture model it was shown that weakly folded variant A (AY286465.1) of 5′UTR promotes the highest level of THRβ expression, while strongly folded variants F (AY286470.1) and F1 (GQ456950) result in low transcription and translation rates and low THRβ expression and in RCC the delicate balance between A and F/F1 variants is disturbed [31]. The gene discussed is THRB; the disease is renal cell carcinoma.