Hypoestrogenemia of hypothalamic origin (defined as estradiol <184 pmol/l (50 pg/ml), FSH <10 IU/l, and luteinizing hormone <10 IU/l) was the most powerful independent predictor of angiographic coronary artery disease (CAD) such that in women with suspected ischemia, those with hypothalamic hypogonadism were at sevenfold (odds ratio = 7.4, 95 % CI of 1.7 to >30) increased risk of obstructive atherosclerotic CAD at coronary angiography [31]. Here, BRD2 is linked to coronary artery disorder.