The latest update conducted by Worthington et al. (10) concluded that only 10 interventions (aloe vera, amifostine, cryotherapy, granulocyte colony-stimulating factor (G-CSF), intravenous glutamine, honey, keratinocyte growth factor, laser irradiation, polymyxin / tobramycin / amphotericin (PTA) antibiotic tablet / paste, and sucralfate) offer some benefit in terms of the prevention or reduction of mucositis associated to cancer therapy. This evidence concerns the gene CSF3 and mucositis.