Our results concerning serum concentrations of MMP-9, TNF-RI, sICAM-1, and IL-1β indicate that CERA treatment using MPG-EPO beside the main action to correct anemia can improve left ventricle function, demonstrate anti-inflammatory action, and may improve endothelial function in nondialyzed CKD patients. This evidence concerns the gene TNFRSF1A and chronic kidney disease.