MAPT and early-onset autosomal dominant Alzheimer disease: In transgenic murine models of Alzheimer's disease, for instance, animals hemizygous for superoxide dismutase 2 exhibit a marked increase in Tau hyperphosphorylation in response to mitochondrial oxidative stress, and daily injections with a manganese-containing catalytic antioxidant were able to ameliorate this potentially damaging effect [81].