KDM3A and cancer: To further investigate the role of KDM3A/JMJD1A in regulating transformation, we knocked it down in HMC-LTR using small interfering RNA (siRNA) and found that KDM3A/JMJD1A deficiency rescued the expression of most cancer-related genes in HMC-LTR to the levels in primary cells (Additional file 1: Figure S6A).