Based on experimentation, it was considered that neem and its ingredients play role in the modulation of various cell signaling pathways. Azadirachta indica hold various ingredients and theses constituents activate the tumour suppressor genes and inactivate the activity of several genes involved in the cancer development and progression such as VEGF, NF-κB, and PI3K/Akt. Here, VEGFA is linked to neoplasm.