A study finding revealed that leaf extract downregulated Bcl-2 expression and upregulated Bim, caspase-8, and caspase-3 expression in the buccal pouch indicating that it has apoptosis inducing effects in the target organ [35] and study results confirmed that leaf extract induced a dose-dependent reduction in chronic lymphocytic leukemia (CLL) cell viability with significant apoptosis observed at 0.06% (w/v) by 24 h [43]. Here, CASP3 is linked to B-cell chronic lymphocytic leukemia.