According to their opinion, none of the three malignancies shared the same origin, since the marrow sample was negative for the BCR-ABL1 transcript at the time of the CLL diagnosis, CLL was in remission at the CML diagnosis, and CML was in complete cytogenetic response at the AML symptoms onset, indicating that this was not a blast crisis. This evidence concerns the gene BCR and B-cell chronic lymphocytic leukemia.