For example, enhanced expression of the Ca2+-channel TRPV6 is a feature of oestrogen receptor negative breast cancers [23] and alteration in the relative levels of the store operated Ca2+-influx pathway regulators STIM1 and STIM2 are a feature of the basal molecular breast cancer subtype and is associated with poor survival [24]. The gene discussed is TRPV6; the disease is breast carcinoma.