YPF resulted in the increased expression of IL-2 (p = 0.0498) but significantly downregulated the expression of TGF-β, IDO, and IL-10 (Figure 5), suggesting that YPF can result in the downregulation of TGF-β, IDO, and IL-10 in tumor microenvironment. Here, TGFB1 is linked to neoplasm.