PDCD1 and hepatocellular carcinoma: When all the 258 HBV-related HCC patients were included for the analysis of OS, Kaplan-Meier curve and log-rank test showed that patients with PD1 +8669 G allele-containing genotypes (AG+GG) had significantly longer survival time than those with PD1 +8669 genotype AA (P < 0.001, Figure 1A).