The TIM3 −1516 genotype GG, which was generally related to longer OS of the HBV-related HCC patients in this study, was suggestively associated with the downregulation of TIM-3 expression in chronic HBV infection [17] and lower tumor grade and less frequent lymph node metastasis in HBV-related HCC [17]. The gene discussed is HAVCR2; the disease is hepatocellular carcinoma.