When those patients were included for the analysis of factors associated with OS, univariate analysis showed that total bilirubin (TBIL), ALB, AFP, Child-Pugh score, tumor size, TNM stage, PD1 +8669 A/G and TIM3 −1516 G/T polymorphisms were significantly associated with patients' survival (Table 2). This evidence concerns the gene PDCD1 and neoplasm.