REST and posterior cortical atrophy: Consistent with the high correlation between REST down-regulation in hypoxia and NED of PCa cells, GSEA revealed that the expression of the 242 genes co-upregulated in hypoxia and REST knockdown was correlated with castration (GSE33316) (Figure 3C, left panel) but not the PCa formation (GSE55945) (Figure 3C, right panel).