In this study, our results were consistent with previous reports that HSPA5 induced colorectal cancer cell migration and invasion in vitro. Moreover, we demonstrated that HSPA5 is required for FOXM1-induced migration and invasion of CRC cells since these effects were markedly attenuated by anti-HSPA5 antibody in LOVO and SW1116 cells. Here, FOXM1 is linked to colorectal carcinoma.