Additionally, it has been reported that FOXM1 increases the metastatic potential of colorectal cancer by positively regulating multiple invasion and metastasis associated molecules, which are involved in the degradation of extra cellular matrix components and angiogenesis such as uPA, uPAR, MMP2, MMP9 and vascular endothelial growth factor (VEGF) [3]. This evidence concerns the gene MMP2 and colorectal cancer.