Many EMT-inducing transcription factors, including Snail, Slug, DNA damage-responsive RNA polymerase-degradation factor (dEF1), septin interacting protein 1 (SIP1), Twist1, forkhead box C2 (FOXC2) and Goosecoid, are associated with tumor invasion and metastasis [(37-40)]. The gene discussed is FOXC2; the disease is neoplasm.