DEFB103A and head and neck cancer: To determine if HPV-associated head and neck cancer produce hBD3 and the role of HPV oncoproteins in modulating hBD3 expression, HPV-16-positive UM-SCC-104 head and neck cancer cells [16] were transfected with HPV-16 E6 or a control siRNA, followed by immunofluorescence microscopy for hBD3 and E6.