TP53 and head and neck squamous cell carcinoma: Transfection of cells with the E6 siRNA blocked expression of both E6 and hBD3 (Figure 2B, left panel), but induced that of p53, in UM-104-SCC cells (Figure 2B, right panel), suggesting the association of hBD3 expression with HPV-16 E6 in HPV-positive HNSCC cells.