In any case, the cancer-associated mutations of the 14-3-3 binding motif surrounding S365 represent an interesting parallel to the Noonan-Syndrome associated RAF1 mutations, affecting the equivalent motif around S259 in Raf-1 [59], and the cancer-associated mutations in the CR2 of A-Raf [60-62]. This evidence concerns the gene RAF1 and Noonan syndrome.