2013). A reduction in serum PON1 activity, as seen in the study, may increase the oxidative stress and makes not only LDL more susceptible to oxidation, but all other serum lipoproteins, including HDL. HDL oxidation may reduce its functionality to induce cellular cholesterol efflux from macrophages. Hence, rather than the absolute levels of HDL, the quality of HDL is maintained by its protective enzyme PON1 and is altered in several pathological conditions such as obesity, myocardial infarction, dyslipidemia and diabetes (Mackness et al. 1993; Watson et al. 1995). The gene discussed is PON1; the disease is metabolic syndrome.