Further analysis of macrophage/dendritic cell subpopulations revealed increased (P < 0.05) infiltration of the well‐described obesity lineage CD11b+ CD11c+ F4/80+ (triple+), CD11b+ CD11c+, and double positive (CD11b+ CD11c− F4/80+) populations in the AT of YO mice, but not in AT of AL or AO (Fig. 3, Panels C–E). Here, ITGAM is linked to obesity due to melanocortin 4 receptor deficiency.