CLEC5A and infection: As shown in Fig. 3c, increased CTX-1 level (from 1.4 ± 0.17 to 2.59 ± 1.1 ng/ml) was observed after DV infection, while anti-CLEC5A mAb reduced CTX-1 release from bone slice (0.39 ± 0.24 ng/ml) (Fig. 3d).