STAT1 and dengue disease: To address this question, osteoclasts derived from human monocytes and STAT1-deficient mouse bone marrow were infected with DV2 PL046 strain (DV serotype 2, clinical isolate in Taiwan) for in vitro study, while mouse adapted strain New Guinea C-N strain (DV serotype 2) was used to infect STAT1-deficient mice for in vivo study, as wild-type mice are resistant to dengue virus infection.