For example, miR-223 51, miR-21 and miR-20a52 alleviated the immunosuppressive potential of MDSCs by targeting MEF2C and STAT3 expression, respectively; whereas miR-155 and miR-21a may be associated with regulating the accumulation and functions of tumor-expanded MDSCs via targeting PTEN, a tumor suppressor gene53. The gene discussed is STAT3; the disease is neoplasm.