Women with HER2 BC tumors showed the opposite pattern, the likelihood of having low DRC values among ER- women is 33% (OR: 0.67, 95% CI: 0.25, 1.79) lower than the likelihood of having low DRC values among ER+ women, even adjusting for different potential confounders; however, this reduction was not statistically significant (p>0.05). This evidence concerns the gene ESR1 and breast cancer.