Programmed cell death 4 (Pdcd4) was initially found to be upregulated during apoptosis.25, 26, 27 So far, Pdcd4 has been well recognized as a tumor suppressor and regulates gene expression through influencing translation and transcription.28, 29, 30 Recently, emerging evidences have demonstrated the involvement of Pdcd4 in inflammatory or metabolic diseases.31, 32, 33 We have previously shown that in response to HFD, Pdcd4 promotes the pathological expansion of epididymal WAT and the development of obesity partially through inhibiting a modulator of lipid homeostasis, LXR-α. This evidence concerns the gene PDCD4 and obesity due to melanocortin 4 receptor deficiency.