The anti-proliferative effects of Pdcd4 on ADSCs exhibits similarity with those on tumor cells, because Pdcd4 has been recognized to inhibit cell proliferation and neoplastic transformation in various types of tumors through several different pathways.26 Here, we point out that Pdcd4 gets in the way of ADSCs entering the S phase by repressing AKT activation. This evidence concerns the gene AKT1 and neoplasm.