As UCP1 is capable of triggering a program of respiration and energy expenditure, the transdifferentiation of ADSCs into UCP1-expressing beige adipocytes might be another explanation that explicates the higher energy consumption in HFD-fed Pdcd4−/− mice as well as the resistance to obesity. The gene discussed is UCP1; the disease is obesity due to melanocortin 4 receptor deficiency.