As shown in Figures 1a and b, early after infection (T5 for pt1 and T3 for pt2), a low frequency of CD4 T-cells was observed in both patients (pt1: 34.1 and pt2: 18.8%) and persisted during all the course of infection reaching the nadir at T13 (pt1: 11.2 and pt2: 13.1%, respectively); in contrast, CD8 T-cells frequency increased early after infection until T11–13. Here, CD8A is linked to infection.