TNFSF11 and neoplasm: In recent years, accumulating evidence showed that DHA inhibits cell growth, arrests cell cycle at the G0/G1 phase and induces apoptotic cell death in different kinds of tumor cells.27, 28, 29 It has been proved that the cytotoxicity of DHA is based on ROS and carbon-centered radical generation.30 The role of ROS during RANKL-induced osteoclastogenesis is essential.