Fig 1D shows CTSB staining in both tumor and nonmalignant epithelial tissues. CTSB staining was weak in nonmalignant epithelial tissue (Fig 1E) but strong in tumor tissue (Fig 1F). Table 2 demonstrates that 34.6% (97/280) of patients were CTSB positive and 65.4% (183/280) were CTSB negative. This evidence concerns the gene CTSB and neoplasm.